研究所

トップページ研究所研究分野紹介分子診断トランスレーショナルリサーチ分野業績

分子診断トランスレーショナルリサーチ分野 業績

2022年

  1. Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Iwai M, Kajino T, Nakatochi M, Yanagisawa K, Hosono Y, Isomura H, Shimada Y, Suzuki M, Taguchi A, Takahashi T. Oncogene. 2022. Online ahead of print.
  2. A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response. Irajizad E, Fahrmann JF, Long JP, Vykoukal J, Kobayashi M, Capello M, Yu CY, Cai Y, Hsiao FC, Patel N, Park S, Peng Q, Dennison JB, Kato T, Tai MC, Taguchi A, Kadara H, Wistuba II, Katayama H, Do KA, Hanash SM, Ostrin EJ. Int J Mol Sci. 23(16):8933. 2022. doi: 10.3390/ijms23168933.
  3. Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma. Fahrmann JF, Tanaka I, Irajizad E, Mao X, Dennison JB, Murage E, Casabar J, Mayo J, Peng Q, Celiktas M, Vykoukal JV, Park S, Taguchi A, Delgado O, Tripathi SC, Katayama H, Soto LMS, Rodriguez-Canales J, Behrens C, Wistuba I, Hanash S, Ostrin EJ. Cancers. 14(10):2543. 2022. doi: 10.3390/cancers14102543.
  4. SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas. Tanaka I, Dayde D, Tai MC, Mori H, Solis L, Tripathi S, Fahrmann J, Unver S, Parhy G, Jain R, Parra E, Murakami Y, Aguilar-Bonavides C, Mino B, Celiktas M, Dhillon D, Casabar J, Nakatochi M, Stingo F, Baladandayuthapani V, Wang H, Katayama H, Dennison J, Lorenzi P, Do KA, Fujimoto J, Behrens C, Ostrin E, Rodriguez-Canales J, Hase T, Fukui T, Kajino T, Kato S, Yatabe Y, Hosoda W, Kawaguchi K, Yokoi K, Chen-Yoshikawa T, Hasegawa Y, Gazdar A, Wistuba I, Hanash S, Taguchi A. J Natl Cancer Inst. J Natl Cancer Inst. 114(2):290-301. 2022. doi: 10.1093/jnci/djab183.

2021年

  1. Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer. Dayde D, Gunther J, Hirayama Y, Weksberg DC, Boutin A, Parhy G, Aguilar-Bonavides C, Wang H, Katayama H, Abe Y, Do KA, Hara K, Kinoshita T, Komori K, Shimizu Y, Tajika M, Niwa Y, Wang YA, DePinho R, Hanash S, Krishnan S, Taguchi A. Cancers. 13(14):3642. 2021. doi: 10.3390/cancers13143642.
  2. Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers. Barua R, Mizuno K, Tashima Y, Ogawa M, Takeuchi H, Taguchi A, Okajima T. Molecules. 26(4):882. 2021. doi: 10.3390/molecules26040882.
  3. Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator. Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, Suzuki K, Yanagisawa K, Suzuki M, Fujishita T, Yamaguchi T, Takahashi M, Takahashi T. Cancer Sci. 112(4):1614-1623. 2021. doi: 10.1111/cas.14825. Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma. Khaledian B, Taguchi A, Shin-Ya K, Kondo-Ida L, Kagaya N, Suzuki M, Kajino T, Yamaguchi T, Shimada Y, Takahashi T. Cancer Sci. 112(3):1225-1234. 2021. doi: 10.1111/cas.14786.
  4. ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma. Myojin Y, Kodama T, Maesaka K, Motooka D, Sato Y, Tanaka S, Abe Y, Ohkawa K, Mita E, Hayashi Y, Hikita H, Sakamori R, Tatsumi T, Taguchi A, Eguchi H, Takehara T. Clin Cancer Res. 27(4):1150-1161. 2021. doi: 10.1158/1078-0432.CCR-20-3382.

2020年

  1. Novel urinary protein biomarker panel for early diagnosis of gastric cancer. Shimura T, Dayde D, Wang H, Okuda Y, Iwasaki H, Ebi M, Kitagawa M, Yamada T, Yamada T, Hanash SM, Taguchi A, Kataoka H. Br J Cancer. 123(11):1656-1664. 2020. doi: 10.1038/s41416-020-01063-5.
  2. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. Gastroenterology. 159(6):2146-2162.e33. 2020. doi: 10.1053/j.gastro.2020.08.018.
  3. A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer. Taguchi A, Fahrmann JF, Hanash SM. Cell Chem Biol. 27(3):253-254. 2020. doi: 10.1016/j.chembiol.2020.03.002.
  4. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Pichler M, Rodriguez-Aguayo C, Nam SY, Dragomir MP, Bayraktar R, Anfossi S, Knutsen E, Ivan C, Fuentes-Mattei E, Lee SK, Ling H, Catela Ivkovic T, Huang G, Huang L, Okugawa Y, Katayama H, Taguchi A, Bayraktar E, Bhattacharya R, Amero P, He WR, Tran AM, Vychytilova-Faltejskova P, Klec C, Bonilla DL, Zhang X, Kapitanovic S, Loncar B, Gafa R, Wang Z, Cristini V, Hanash SM, Bar-Eli M, Lanza G, Slaby O, Goel A, Rigoutsos I, Lopez-Berestein G, Calin GA. Gut. 69(10):1818-1831. 2020. doi: 10.1136/gutjnl-2019-318903.

2019年

  1. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Nature. 568(7752):410-414. 2019. doi: 10.1038/s41586-019-1062-1.
  2. Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity. Capello M, Vykoukal JV, Katayama H, Bantis LE, Wang H, Kundnani DL, Aguilar-Bonavides C, Aguilar M, Tripathi SC, Dhillon DS, Momin AA, Peters H, Katz MH, Alvarez H, Bernard V, Ferri-Borgogno S, Brand R, Adler DG, Firpo MA, Mulvihill SJ, Molldrem JJ, Feng Z, Taguchi A, Maitra A, Hanash SM. Nat Commun. 10(1):254. 2019. doi: 10.1038/s41467-018-08109-6.
  3. Harnessing Immune Response to Malignant Lung Nodules. Promise and Challenges. Taguchi A, Arenberg D. Am J Respir Crit Care Med. 199(10):1184-1186. doi: 10.1164/rccm.201811-2188ED.
  4. A Plasma-Derived Protein-Metabolite Multiplexed Panel for Early-Stage Pancreatic Cancer. Fahrmann JF, Bantis LE, Capello M, Scelo G, Dennison JB, Patel N, Murage E, Vykoukal J, Kundnani DL, Foretova L, Fabianova E, Holcatova I, Janout V, Feng Z, Yip-Schneider M, Zhang J, Brand R, Taguchi A, Maitra A, Brennan P, Max Schmidt C, Hanash S. J Natl Cancer Inst. 111(4):372-379. 2019. doi: 10.1093/jnci/djy126.

2018年

  1. Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins. Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium for Early Detection of Lung Cancer, Guida F, Sun N, Bantis LE, Muller DC, Li P, Taguchi A, Dhillon D, Kundnani DL, Patel NJ, Yan Q, Byrnes G, Moons KGM, Tjonneland A, Panico S, Agnoli C, Vineis P, Palli D, Bueno-de-Mesquita B, Peeters PH, Agudo A, Huerta JM, Dorronsoro M, Barranco MR, Ardanaz E, Travis RC, Byrne KS, Boeing H, Steffen A, Kaaks R, Husing A, Trichopoulou A, Lagiou P, La Vecchia C, Severi G, Boutron-Ruault MC, Sandanger TM, Weiderpass E, Nost TH, Tsilidis K, Riboli E, Grankvist K, Johansson M, Goodman GE, Feng Z, Brennan P, Johansson M, Hanash SM. JAMA Oncol. 4(10):e182078. 2018. doi: 10.1001/jamaoncol.2018.2078.
  2. HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. Shiels MS, Kirk GD, Drummond MB, Dhillon D, Hanash SM, Taguchi A, Engels EA. J Infect Dis. 217(3):413-417. 2018. doi: 10.1093/infdis/jix510.

2017年までの主要な業績

  1. Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. Celiktas M, Tanaka I, Tripathi SC, Fahrmann JF, Aguilar-Bonavides C, Villalobos P, Delgado O, Dhillon D, Dennison JB, Ostrin EJ, Wang H, Behrens C, Do KA, Gazdar AF, Hanash SM, Taguchi A. J Natl Cancer Inst. 109(3):1-9. 2017. doi: 10.1093/jnci/djw231.
  2. Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer. Capello M, Bantis LE, Scelo G, Zhao Y, Li P, Dhillon DS, Patel NJ, Kundnani DL, Wang H, Abbruzzese JL, Maitra A, Tempero MA, Brand R, Firpo MA, Mulvihill SJ, Katz MH, Brennan P, Feng Z, Taguchi A, Hanash SM. J Natl Cancer Inst. 109(4):djw266. 2017. doi: 10.1093/jnci/djw266.
  3. Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome. Tripathi SC, Peters HL, Taguchi A, Katayama H, Wang H, Momin A, Jolly MK, Celiktas M, Rodriguez-Canales J, Liu H, Behrens C, Wistuba II, Ben-Jacob E, Levine H, Molldrem JJ, Hanash SM, Ostrin EJ. Proc Natl Acad Sci U S A. 113(11):E1555-64. 2016. doi: 10.1073/pnas.1521812113.
  4. Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non-Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B. Wikoff WR, Hanash S, DeFelice B, Miyamoto S, Barnett M, Zhao Y, Goodman G, Feng Z, Gandara D, Fiehn O, Taguchi A. J Clin Oncol. 33(33):3880-6. 2015. doi: 10.1200/JCO.2015.61.7779.
  5. Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. Capello M, Lee M, Wang H, Babel I, Katz MH, Fleming JB, Maitra A, Wang H, Tian W, Taguchi A, Hanash SM. J Natl Cancer Inst. 107(8):djv132. 2015. doi: 10.1093/jnci/djv132.
  6. Pro-surfactant protein B as a biomarker for lung cancer prediction. Sin DD, Tammemagi CM, Lam S, Barnett MJ, Duan X, Tam A, Auman H, Feng Z, Goodman GE, Hanash S, Taguchi A. J Clin Oncol. 31(36):4536-43. 2013. doi: 10.1200/JCO.2013.50.6105.
  7. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faca VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Cancer Cell. 20(3):289-99. 2011. doi: 10.1016/j.ccr.2011.08.007.
  8. The grand challenge to decipher the cancer proteome. Hanash S, Taguchi A. Nat Rev Cancer. 10(9):652-60. 2010. doi: 10.1038/nrc2918.