研究所

トップページ研究所研究分野紹介腫瘍制御学分野業績

腫瘍制御学分野 業績

【代表的な原著論文】（* corresponding author）

  1. Mitani F, Hayasaka R, Hirayama A, *Oneyama C. SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells. Biol Pharm Bull. 45(10):1572-1580, 2022. (PMID: 36184518) 
  2. Hikita T, *Oneyama C. Quantification and Imaging of Exosomes via Luciferase-Fused Exosome Marker Proteins: ExoLuc System. Methods Mol Biol. 2524:281-290, 2022. (PMID: 35821479)
  3. Mitani F, Lin J, Sakamoto T, Uehara R, Hikita T, Yoshida T, Setiawan A, Arai M, *Oneyama C. Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function. Sci Rep. 12(1):6674, 2022. (PMID: 35461323) 
  4. Hikita T, Uehara R, Itoh RE, Mitani F, Miyata M, Yoshida T, Yamaguchi R, *Oneyama C. MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function. Cancer Sci. 113(4):1264-1276, 2022. (PMID: 35108425)
  5. Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T. A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their diseaseassociated regulation. Nat Commun. 13(1):83, 2022. (PMID: 35013169) 
  6. Kunou S, Shimada K, Takai M, Sakamoto A, Aoki T, Hikita T, Kagaya Y, Iwamoto E, Sanada M, Shimada S, Hayakawa F, Oneyama C, Kiyoi H. Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma. Oncogene, 40(23):3989-4003, 2021. (PMID: 33994542)
  7. Ito RE, Oneyama C, Aoki K. Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction. PLoS One, 16(4): e0249388, 2021. (PMID: 33793658) 
  8. Nishimura T, Oyama T, Hu HT, Fujioka T, Hanawa-Suetsugu K, Ikeda K, Yamada S, Kawana H, Saigusa D, Ikeda H, Kurata R, Oono-Yakura K, Kitamata M, Kida K, Hikita T, Mizutani K, Yasuhara K, Mimori-Kiyosue Y, Oneyama C, Kurimoto K, Hosokawa Y, Aoki J, Takai Y, Arita M, Suetsugu S. Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells. Dev Cell, 56(6), 842-859, 2021. (PMID: 33756122)
  9. Hikita T, Miyata M, Watanabe R, *Oneyama C. In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter. Sci Rep, 10(1): 16616, 2020. (PMID: 33024173)
  10. Watanabe R, Miyata M, *Oneyama C. Rictor promotes tumor progression of rapamycin-insensitive triple-negative breast cancer cells. Biochem Biophys Res Commun, 531(4), 636-642, 2020. (PMID: 32819718)
  11. Okuzaki D, Yamauchi T, Mitani F, Miyata M, Ninomiya Y, Watanabe R, Akamatsu H, *Oneyama C. c-Src promotes tumor progression through downregulation of microRNA-129-1-3p. Cancer Sci. 111(2), 418-428, 2020. (PMID: 31799727)
  12. Hikita T, Kuwahara A, Watanabe R, Miyata M, *Oneyama C. Src in endosomal membranes promotes exosome secretion and tumor progression. Sci Rep, 9(1), 3265, 2019. (PMID: 30824759)
  13. Hikita T, Miyata M, Watanabe R, *Oneyama C. Sensitive and rapid quantification of exosomes by fusing luciferase to exosome marker proteins. Sci Rep, 8(1), 14035, 2018. (PMID: 30232365)
  14. Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, *Oneyama C. MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression. Genes Cells, 23(8), 688-701, 2018. (PMID: 29962093)
  15. *Oneyama C, Yoshikawa Y, Ninomiya Y, Iino T, Tsukita S, Okada M. Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression. Oncogene, 35(4), 501-512, 2016. (PMID: 25867068)
  16. Matsuyama R, Okuzaki D, Okada M, *Oneyama C.: miR-27b suppresses tumor progression by regulating ARFGEF1 and the focal adhesion signaling. Cancer Science, 107(1): 28-35, 2016. (PMID: 26473412)
  17. Kakumoto K, Ikeda J, Okada M, Morii E, *Oneyama C.: mLST8 promotes mTOR-mediated tumor progression. PLoS One, 10(4): e0119015, 2015. (PMID: 25906254)
  18. Kajiwara K, Yamada T, Bamba T, Fukusaki E, Imamoto F, Okada M, *Oneyama C.: c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions. Biochem J, 458(1): 81-93, 2014. (PMID: 24266736)
  19. *Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.: MiR-424/503-mediated Rictor upregulation promotes tumor progression. PLoS One, 8(11): e80300, 2013. (PMID: 24244675)
  20. *Oneyama C, Morii E, Okuzaki D, Takahashi Y, Ikeda J, Wakabayashi N, Akamatsu H, Tsujimoto M, Nishida T, Aozasa K, Okada M.: MicroRNA-mediated upregulation of integrin-linked kinase is crucial for Src-induced tumor progression. Oncogene, 31(13), 1623-1635, 2012. (PMID: 21860426)
  21. *Oneyama C, Ikeda J, Okuzaki D, Suzuki K, Kanou T, Shintani Y, Morii E, Okumura M, Aozasa K, Okada M.: MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways. Oncogene, 30(32): 3489-3501, 2011. (PMID: 21383697)
  22. Kuroiwa M, Oneyama C, Nada S, Okada M.: The guanine nucleotide exchange factor Arhgef5 plays crucial roles in c-Src-induced podosome formation. J Cell Sci, 124: 1726-1738, 2011. (PMID: 21525037)
  23. Suzuki K, Oneyama C, Kimura H, Tajima S, Okada M.: Downregulation of the tumor suppressor Cbp/PAG1 is mediated by epigenetic histone modifications via the MAPK/PI3K pathway. J Biol Chem, 286(18): 15698-15706, 2011. (PMID: 21388951)
  24. Kanou T, Oneyama C, Kawahara K, Okimura A, Ohta M, Ikeda N, Shintani Y, Okumura M, Okada M.: The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation. Mol Cancer Res, 9(1): 103-114, 2011. (PMID: 21156787)
  25. Hikita T, Oneyama C, Okada M.: Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. Genes Cells, 15(10): 1051-1062, 2010. (PMID: 20825494)
  26. Oneyama C, Iino T, Saito K, Suzuki K, Ogawa A, Okada M.: Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain. Mol Cell Biol, 29(24): 6462-6472, 2009. (PMID: 19822664)
  27. Inoue K, Sone T, Oneyama C, Nishiumi F, Kishine H, Sasaki Y, Andoh T, Okada M, Chesnut JD, Imamoto F.: A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression. Gene Therapy, 16(12): 1383-1394, 2009. (PMID: 19759563)
  28. Oneyama C, Hikita T, Enya K, Dobenecker MW, Saito K, Nada S, Tarakhovsky A, Okada M. : The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. Mol Cell, 30(4): 426-436, 2008. (PMID: 18498747)
  29. Saito K, Enya K, Oneyama C, Hikita T, Okada M.: Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit. Biochem Biophys Res Commun, 366(4): 969-975, 2008. (PMID: 18086565)
  30. Oneyama C, Hikita T, Nada S, Okada M.: Functional dissection of transformation by c-Src and v-Src. Genes Cells, 13(1): 1-12, 2008. (PMID: 18173743)
  31. Yagi R, Waguri S, Sumikawa Y, Nada S, Oneyama C, Itami S, Schmedt C, Uchiyama Y, Okada M.: C-terminal Src kinase controls development and maintenance of mouse squamous epithelia. EMBO J, 26(5): 1234-1244, 2007. (PMID: 17304209)
  32. Sukezane T, Oneyama C, Kakumoto K, Shibutani K, Hanafusa H and Akagi T.: Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras. Oncogene, 24: 5648-5655, 2005. (PMID: 16007212)
  33. Oneyama C, Agatsuma T, Kanda Y, Nakano H, Sharma SV, Nakano H, Narazaki F and Tatsuta K.: Synthetic Inhibitors of Proline-Rich Ligand-Mediated Protein-Protein Interaction: Potent Analogs of UCS15A. Chemistry & Biology, 10: 443-451, 2003. (PMID: 12770826)
  34. Oneyama C, Nakano H and Sharma SV.: UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene, 21: 2037-2050, 2002. (PMID: 11960376)
  35. Sharma SV, Oneyama C, Yamashita Y, Nakano H, Sugawara K, Hamada M, Kosaka N and Tamaoki T.: UCS15A, a non-kinase inhibitor of Src signal transduction. Oncogene, 20: 2068-2079, 2001. (PMID: 11360191)

総説など

  1. 小根山千歳：「がんシグナルによる細胞外小胞の分泌亢進メカニズム」実験医学増刊号「EVs 細胞外小胞の生物学」39(20), 3141-3147, 2021
  2. 小根山千歳：「チロシンキナーゼ：分子標的薬を極める―基礎から臨床まで―」産科と婦人科,、診断と治療社、87(10), 1150-1155, 2020
  3. 小根山千歳ら：「脂質ラフトによるSrcの空間的制御とがん進展」実験医学増刊号「知る・見る・活かす！シグナリング研究2015」33(10):82-87, 羊土社（2015）
  4. Oneyama C. et al. : MicroRNAs as the fine-tuners of Src oncogenic signaling. J Biochem, 157(6): 431-438, 2015. （PMID: 25862810）
  5. 小根山千歳：「Srcがん形質におけるmicroRNA異常とmTORシグナル」次世代がん戦略研究update がん基盤生物学－革新的シーズ育成に向けて－, 248-253, 南山堂（2013）
  6. 小根山千歳ら：「細胞膜ミクロドメイン”ラフト”を介するSrcがん化シグナル制御機構」蛋白質核酸酵素、54(3): 201-211, 共立出版（2009）
  7. 小根山千歳ら：「チロシンキナーゼシグナルとがん形質発現」実験医学増刊号「シグナル伝達2008-2009」26(15): 41-48, 羊土社（2008）