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トップページ研究所研究分野紹介腫瘍免疫応答研究分野業績

腫瘍免疫応答研究分野 業績

研究業績

前職における主な研究業績

  1. *Tsukasa Nabekura, Soichi Matsuo, Akira Shibuya (*corresponding author). Concanavalin A-induced acute liver injury in mice. Current Protocols in Immunology, 2024 in press. 
  2. Elfira Amalia Deborah, *Tsukasa Nabekura, Kazuko Shibuya, Akira Shibuya (*corresponding author). THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling. Journal of Immunology 2024;212:1819-1828. 
  3. *Tsukasa Nabekura, Elfira Amalia Deborah, Saeko Tahara, Yuya Arai, Paul E. Love, Koichiro Kako, Akiyoshi Fukamizu, Masafumi Muratani, Akira Shibuya (*corresponding author). Themis2 regulates natural killer cell memory function and formation. Nature Communications 2023;14:7200. 
  4. Soichi Matsuo, *Tsukasa Nabekura, Kenshiro Matsuda, Kazuko Shibuya, Akira Shibuya (*corresponding author). DNAM-1 immunoreceptor protects mice from concanavalin A-induced acute liver injury by reducing neutrophil infiltration. Journal of Immunology 2023;211:954-963. 
  5. Takuma Asahi, Shinya Abe, Guangwei Cui, Akihiro Shimba, Tsukasa Nabekura, Hitoshi Miyachi, Satsuki Kitano, Keizo Ohira, Johannes M Dijkstra, Masaki Miyazaki, Akira Shibuya, Hiroshi Ohno, Koichi Ikuta. Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches. eLife, 2023;12:e84209. 
  6. Oscar A. Aguilar, Maria D.R. Gonzalez-Hinojosa, Janice S. Arakawa-Hoyt, Alberto J. Millan, Dagmar Gotthardt, Tsukasa Nabekura, Lewis L. Lanier. The CD16 and CD32b Fc-gamma receptors regulate antibody-mediated responses in mouse natural killer cells. Journal of Leukocyte Biology 2023;113:27-40. 
  7. Tsukasa Nabekura, Akira Shibuya. ILC1: Guardians of the Oral Mucosa Against Enemy Viruses. Immunity 2021;54:196-198. 
  8. Tsukasa Nabekura, Akira Shibuya. Type 1 innate lymphoid cells: Soldiers at the front line of immunity. Biomedical Journal  2021;44:115-122. 
  9. Tsukasa Nabekura, Luke Riggan, Andrew D. Hildreth, Timothy E. O’Sullivan, Akira Shibuya. Type 1 innate lymphoid cells protect mice from acute liver injury via interferon-γ secretion for upregulating Bcl-xL expression in hepatocytes. Immunity 2020;52:96-108. 
  10. Hideyuki Yoshida, Caleb A. Lareau, Ricardo N. Ramirez, Samuel A. Rose, Barbara Maier, Aleksandra Wroblewska, Fiona Desland, Aleksey Chudnovskiy, Arthur Mortha, Claudia Dominguez, Julie Tellier, Edy Kim, Dan Dwyer, Susan Shinton, Tsukasa Nabekura, YiLin Qi, Bingfei Yu, Michelle Robinette, Ki-Wook Kim, Amy Wagers, Andrew Rhoads, Stephen L. Nutt, Brian D. Brown, Sara Mostafavi, Jason D. Buenrostro, Christophe Benoist. The cis-regulatory atlas of the mouse immune system. Cell 2019;176:897-912. 
  11. Tsukasa Nabekura, Zhiying Chen, Casey Schroeder, Taeju Park, Eric Vivier, Lewis L. Lanier, Dongfang Liu. Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. Journal of Immunology 2018;200:3420-3428. 
  12. Tsukasa Nabekura, Dagmar Gotthardt, Kouta Niizuma, Tihana Trsan, Tina Jenus, Stipan Jonjic, Lewis L. Lanier . Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. Journal of Immunology 2017;199:1567-1571. 
  13. Tsukasa Nabekura, Lewis L. Lanier . Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection. Journal of Experimental Medicine 2016;213:2745-2758. 
  14. Daniel F Dwyer, Nora A Barrett, Edy Y Kim, Michael B Brenner, Laura Shaw, Bingfei Yu, Ananda Goldrath, Sara Mostafavi, Aviv Regev, Andrew Rhoades, Devapregasan Moodley, Hideyuki Yoshida, Diane Mathis, Christophe Benoist, Tsukasa Nabekura, Viola Lam, Lewis L Lanier, Brian Brown, Miriam Merad, Viviana Cremasco, Shannon Turley, Paul Monach, Michael L Dustin, Yuesheng Li, Susan A Shinton, Richard R Hardy, Tal Shay, Yilin Qi, Katelyn Sylvia, Joonsoo Kang, Keke Fairfax, Gwendalyn J Randolph, Michelle L Robinette, Anja Fuchs, K Frank Austen. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nature Immunology 2016;17:878-887. 
  15. Tsukasa Nabekura, Lewis L. Lanier. Activating receptors for self-MHC class I enhance effector functions and memory differentiation of NK cells during mouse cytomegalovirus infection. Immunity 2016;45:74-82. 
  16. Tsukasa Nabekura, Jean-Philippe Girard, Lewis L. Lanier. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. Journal of Immunology 2015;194:5948-5952. 
  17. Michelle L Robinette, Anja Fuchs, Victor S Cortez, Jacob S Lee, Yaming Wang, Scott K Durum, Susan Gilfillan, Sara Mostafavi, Aviv Regev, Edy Y Kim, Dan F Dwyer, Michael B Brenner, K Frank Austen, Andrew Rhoads, Devapregasan Moodley, Hideyuki Yoshida, Diane Mathis, Christophe Benoist, Tsukasa Nabekura, Viola Lam, Lewis L Lanier, Brian Brown, Miriam Merad, Viviana Cremasco, Shannon Turley, Paul Monach, Michael L Dustin, Yuesheng Li, Susan A Shinton, Richard R Hardy, Tal Shay, Yilin Qi, Katelyn Sylvia, Joonsoo Kang, Keke Fairfax, Gwendalyn J Randolph, Marco Colonna. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nature Immunology 2015;16:306-317. 
  18. Tsukasa Nabekura, Lewis L. Lanier. Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. Journal of Experimental Medicine 2014;211:2455-2465. 
  19. Tsukasa Nabekura, Minoru Kanaya, Akira Shibuya, Guo Fu, Nicholas R.J. Gascoigne, Lewis L. Lanier. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection. Immunity 2014;40:225-234. 
  20. Gundula Min-Oo, Yosuke Kamimura, Deborah W. Hendricks, Tsukasa Nabekura, Lewis L. Lanier . Natural killer cells: walking three paths down memory lane. Trends in Immunology 2013;34:251-258. 
  21. Tsukasa Nabekura, Kazuko Shibuya, Akira Shibuya. Reply to Seth et al.: DNAX accessory molecule-1 (DNAM-1) plays an important role in alloreactive CD8+ T cells responsible for the exacerbation of acute graft-versus-host disease. Proceedings of the National Academy of Sciences of the United States of America 2011;108:E34. 
  22. Tsukasa Nabekura, Kazuko Shibuya, Eri Takenaka, Hirayasu Kai, Kai Shibata, Yumi Yamashita, Kyoichi Harada, Satoko Tahara-Hanaoka, Shin-ichiro Honda, Akira Shibuya. Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice. Proceedings of the National Academy of Sciences of the United States of America 2010;107:18593-18598. 
  23. Tsukasa Nabekura, Toshiro Nagasawa, Hiromitsu Nakauchi, Onodera Masafumi. An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2. Cancer Immunology, Immunotherapy 2008;57:611-622.